Subsampling receivers with applications to software defined radio systems

Este trabajo de tesis propone la utilización sistemas basados en submuestreo como una alternativa para la implementación de la etapa de down-conversion de los receptores de radio frecuencia (RF) empleados para aplicaciones multi-estándar y SDR (Software Defined Radio). El objetivo principal será el de optimizar el diseño en cuanto a flexibilidad y simplicidad, las cuales son propiedades inherentes en los sistemas basados en submuestreo. Por tanto, como reducir el número de componentes al mínimo es clave cuando un mismo receptor procesa diferentes estándares de comunicación, las arquitecturas basadas en submuestreo han sido seleccionadas, donde la reusabilidad de los componentes empleados es posible, así como la reducción de los costes totales de los receptores de comunicación y de los equipos de certificación que emplean estas arquitecturas. Un motivo adicional por el que los sistemas basados en submuestreo han sido seleccionados es el concerniente a la topología del receptor. Como la idea de la tecnología SDR es implementar todas las funcionalidades del receptor (filtrado, amplificación) en el dominio digital, el convertidores analógico-digital (ADC) deberá estar localizado en la cadena de recepción lo más cerca posible a la antena, siendo el objetivo final el convertir la señal directamente de RF a digital. Sin embargo, con los actuales ADC no es posible implementar esta idea debido al alto ancho de banda que necesitarían sin perder resolución para cubrir las especificaciones de los estándares de comunicaciones inalámbricas. Por tanto, los sistemas basados en submuestreo se presentan como la opción más adecuada para implementar este tipo de sistemas debido a que pueden muestrear la señal de entrada por debajo de la tasa de Nyquist, si se cumplen ciertas restricciones en cuanto a la elección de la frecuencia de muestreo. De este modo, los requerimientos del ADC serán relajados ya que, usando estas arquitecturas, este componente procesará la señal a frecuencias intermedias. Una vez se han introducido los conceptos principales de las técnicas de submuestreo, esta tesis doctoral presenta el diseño de una tarjeta de adquisición de datos basada en submuestreo con la finalidad de ser implementada como un receptor de test y certificación de banda ancha. El sistema propuesto proporciona una alta resolución para un elevado ancho de banda, a partir del uso de un S&H de bajo jitter y de un convertidor analógico digital ADC que trabaja a frecuencias intermedias. El sistema es implementado usando dispositivos comerciales en una placa de circuito impreso diseñada y fabricada, y cuya caracterización experimental muestra una resolución de más 8 bits para un ancho de banda analógico de 20 MHz. Concretamente, la resolución medida será mayor de 9 bits hasta una frecuencia de entrada de 2.9 GHz y mayor de 8 bits para una frecuencia de entrada de hasta 6.5 GHz, lo cual resulta suficiente para cubrir los requerimientos de la mayor parte de los actuales estándares de comunicaciones inalámbricas (GPS, GSM, GPRS, UMTS, Bluetooth, Wi-Fi, WiMAX). Sin embargo, los receptores basados en submuestreo presentan algunos importantes inconvenientes, como son adicionales fuentes de ruido (jitter y plegado de ruido térmico) y una dificultad añadida para implementarlo en escenarios multi-banda y no lineales. Acerca del plegado de ruido en la banda de interés, esta tesis propone el uso de una técnica basada en una arquitectura de reloj múltiple con el objetivo de aumentar la resolución y cubrir un número mayor de estándares para su test y certificación. Empleando una frecuencia de muestreo mayor para el caso del S&H, se conseguirá reducir este efecto, aumentando la resolución en aproximadamente 0.5-1 bit respecto al caso de sólo usar una fuente de reloj. Las expresiones teóricas de esta mejora son desarrolladas y presentadas en esta tesis, siendo posteriormente corroboradas de modo experimental. Por otra parte, esta tesis también propone novedosas técnicas para la aplicación de estos sistemas de submuestreo en entornos multi-banda y no lineales, los cuales presentan desafíos adicionales por el hecho de existir la posibilidad de solapamiento entre la señal de interés y los otros canales de comunicación, así como de solapamiento con sus armónicos. De este modo, esta tesis extiende el uso de los sistemas basados en submuestreo para este tipo de entornos, proponiendo técnicas para la elección de la frecuencia óptima de muestreo que evitan el solapamiento entre señales, a la vez que consiguen incrementar la resolución del receptor. Finalmente, se presentará la optimización en cuanto a características de ruido de un receptor concreto para aplicaciones de banda dual en entornos no lineales. Dicho receptor estará basado en las técnicas de reloj múltiple presentadas anteriormente y en una estructura de multi-filtro entre el S&H y el ADC. El sistema diseñado podrá emplearse para diversas aplicaciones a ambos lados de la cadena de comunicación, tal como en receptores de detección de espectro para radio cognitiva, o implementando el bucle de realimentación de un transmisor para la linealización de amplificadores de potencia. Por tanto, la presente tesis doctoral cuenta con tres contribuciones diferenciadas. La primera de ellas es la dedicada al diseño de un prototipo de recepción multi-estándar basado en submuestreo para aplicaciones de test y certificación. La segunda aportación es la dedicada a la optimización de las especificaciones de ruido a partir de las técnicas presentadas basadas en reloj múltiple. Por último, la tercera contribución principal es la relacionada con la extensión de este tipo de técnicas a sistemas multi-banda en entornos no lineales. Todas estas contribuciones han sido estudiadas teóricamente y experimentalmente validadas

Analog‐to‐Digital Conversion for Cognitive Radio: Subsampling, Interleaving, and Compressive Sensing

This chapter explores different analog-to-digital conversion techniques that are suitable to be implemented in cognitive radio receivers. This chapter details the fundamentals, advantages, and drawbacks of three promising techniques: subsampling, interleaving, and compressive sensing. Due to their major maturity, subsampling- and interleaving-based systems are described in further detail, whereas compressive sensing-based systems are described as a complement of the previous techniques for underutilized spectrum applications. The feasibility of these techniques as part of software-defined radio, multistandard, and spectrum sensing receivers is demonstrated by proposing different architectures with reduced complexity at circuit level, depending on the application requirements. Additionally, the chapter proposes different solutions to integrate the advantages of these techniques in a unique analog-to-digital conversion process

Passive RFID-Based Inventory of Traffic Signs on Roads and Urban Environments

This paper presents a system with location functionalities for the inventory of traffic signs based on passive RFID technology. The proposed system simplifies the current video-based techniques, whose requirements regarding visibility are difficult to meet in some scenarios, such as dense urban areas. In addition, the system can be easily extended to consider any other street facilities, such as dumpsters or traffic lights. Furthermore, the system can perform the inventory process at night and at a vehicle’s usual speed, thus avoiding interfering with the normal traffic flow of the road. Moreover, the proposed system exploits the benefits of the passive RFID technologies over active RFID, which are typically employed on inventory and vehicular routing applications. Since the performance of passive RFID is not obvious for the required distance ranges on these in-motion scenarios, this paper, as its main contribution, addresses the problem in two different ways, on the one hand theoretically, presenting a radio wave propagation model at theoretical and simulation level for these scenarios; and on the other hand experimentally, comparing passive and active RFID alternatives regarding costs, power consumption, distance ranges, collision problems, and ease of reconfiguration. Finally, the performance of the proposed on-board system is experimentally validated, testing its capabilities for inventory purposesMinisterio de Economía y Competitividad TEC2016-80396-C2-2-

Subsampling OFDM-based ultrasonic data communication through metallic channels for monitoring of cargo containers

An enhanced ultrasonic communication system based on piezoelectric transducers for monitoring of goods in cargo containers is presented. The proposed system consists of several sensors placed inside the container, whose data are collected and transmitted outside it. Data transmission is carried out by an ultrasonic communication channel, in order to avoid drilling the wall of the container. The proposed data communication system is based on the transmission of a 128-OFDM signal. This modulation has been chosen due to its robustness to channels with frequency-selective fading and its spectrum efficiency. In order to increase the signal bandwidth and to reduce the power consumption at the internal node (transmitter), the proposed system exploits the non-linearity of the metallic channel to transmit at higher resonance frequencies. Moreover, power consumption at the external node (receiver) is reduced by using a subsampling based receiver, which allows its implementation by low-cost electronics.This work was supported by the Spanish Ministry of Economy and Competitiveness under Projects TEC2016-80396-C2-2-R and TEC2016-80396-C2-1-

Passive RFID-Based Inventory of Traffic Signs on Roads and Urban Environments

This paper presents a system with location functionalities for the inventory of traffic signs based on passive RFID technology. The proposed system simplifies the current video-based techniques, whose requirements regarding visibility are difficult to meet in some scenarios, such as dense urban areas. In addition, the system can be easily extended to consider any other street facilities, such as dumpsters or traffic lights. Furthermore, the system can perform the inventory process at night and at a vehicle’s usual speed, thus avoiding interfering with the normal traffic flow of the road. Moreover, the proposed system exploits the benefits of the passive RFID technologies over active RFID, which are typically employed on inventory and vehicular routing applications. Since the performance of passive RFID is not obvious for the required distance ranges on these in-motion scenarios, this paper, as its main contribution, addresses the problem in two different ways, on the one hand theoretically, presenting a radio wave propagation model at theoretical and simulation level for these scenarios; and on the other hand experimentally, comparing passive and active RFID alternatives regarding costs, power consumption, distance ranges, collision problems, and ease of reconfiguration. Finally, the performance of the proposed on-board system is experimentally validated, testing its capabilities for inventory purposes

Low-Power Transit Time-Based Gas Flow Sensor with Accuracy Optimization

In this paper, a fully designed ultrasonic transit time-based gas flow sensor is presented. The proposed sensor has been optimized in terms of accuracy, sensitivity, and power consumption at different design stages: mechanical design of the sensor pipe, piezoelectric transducer configuration and validation over temperature, time of flight detection algorithm, and electronics design. From the optimization and integration of each design part, the final designed gas flow sensor is based on the employment of 200 kHz-piezoelectric transducers mounted in a V-configuration and on the implementation of a cross-correlation algorithm based on the Hilbert Transform for time-of-flight detection purposes. The proposed sensor has been experimentally validated at different flow rates and temperatures, and it fully complies with the accuracy specifications required by the European standard EN14236, placing the proposed design into the state of the art of ultrasonic gas flow sensors regarding cost, accuracy, and power consumption, the latter of which is crucial for implementing smart gas meters that are able to autonomously operate as IoT devices by extending their battery life

Study protocol for a randomized clinical trial to assess 7 versus 14-days of treatment for Pseudomonas aeruginosa bloodstream infections (SHORTEN-2 trial)

Background Research priorities in Antimicrobial Stewardship (AMS) have rapidly evolved in the last decade. The need for a more efficient use of antimicrobials have fueled plenty of studies to define the optimal duration for antibiotic treatments, and yet, there still are large areas of uncertainty in common clinical scenarios. Pseudomonas aeruginosa has been pointed as a priority for clinical research, but it has been unattended by most randomized trials tackling the effectiveness of short treatments. The study protocol of the SHORTEN-2 trial is presented as a practical example of new ways to approach common obstacles for clinical research in AMS. Objective To determine whether a 7-day course of antibiotics is superior to 14-day schemes for treating bloodstream infections by P. aeruginosa (BSI-PA). Methods A superiority, open-label, randomized controlled trial will be performed across 30 Spanish hospitals. Adult patients with uncomplicated BSI-PA will be randomized to receive a 7 versus 14-day course of any active antibiotic. The primary endpoint will be the probability for the 7-day group of achieving better outcomes than the control group, assessing altogether clinical effectiveness, severe adverse events, and antibiotic exposure through a DOOR/RADAR analysis. Main secondary endpoints include treatment failure, BSI-PA relapses, and mortality. A superiority design was set for the primary endpoint and non-inferiority for treatment failure, resulting in a sample size of 304 patients. Conclusions SHORTEN-2 trial aligns with some of the priorities for clinical research in AMS. The implementation of several methodological innovations allowed overcoming common obstacles, like feasible sample sizes or measuring the clinical impact and unintended effects

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

BackgroundWe previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in similar to 80% of cases.MethodsWe report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.ResultsNo gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P=1.1x10(-4)) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR=3.70[95%CI 1.3-8.2], P=2.1x10(-4)). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR=19.65[95%CI 2.1-2635.4], P=3.4x10(-3)), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR=4.40[9%CI 2.3-8.4], P=7.7x10(-8)). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD]=43.3 [20.3] years) than the other patients (56.0 [17.3] years; P=1.68x10(-5)).ConclusionsRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old